George Michailidis
Department of Statistics
University of Michigan
439 West Hall
Ann Arbor, MI 48109-1092
Phone: (734) 763-3498
Fax : (734) 763-4676
Email:
gmichail@umich.edu
URL:
http://www.stat.lsa.umich.edu/~gmichail
One of the major issues of the molecular biological community is
the need and technical difficulty to setup and maintain distributed
databases to be linked, coordinated, and integrated
over the web as the basis for analyzing and interpreting biological
organisms. The Distributed Cooperative Apache (DC-Apache) web server
system, which is one of the main components of the proposed research,
will provide the necessary infrastructure for searching, browsing and
sharing biological and genomic data.
(i) choice of the loss function
(ii) choice of the normalization constraint used, in order to make the optimization problem well posed
(iii) design of efficient and robust algorithms.
Our results have shown that some of the choices lead to non-informative solutions, while other choices emphasize particular aspects of the data. Particular attention is also paid to the stability of the resulting representation. The proposed information visualization framework aims at providing an illuminating and accurate low dimensional representation of the data, where the dependencies and interdependencies between objects are easier to understand, describe and characterize. Nevertheless, one may always pose the question of whether the patterns uncovered in the graphical displays are real or mere ``chance'' effects. Thus, stable representations (i.e. those where small changes in the “input” lead to small and unimportant changes in the “output”) are most informative, since they capture significant patterns in the data.